鲁浩，男，山东菏泽人，博士，讲师，于2023年6月毕业于华中农业大学，获农学博士学位，现就职于菏泽学院药学院。
擅长抗菌抗癌抗病毒药物的设计与改造评估，药物增效剂，细胞治疗，以及新型生物抗菌肽的设计与表达，擅长靶点设计，挖掘，评估等工作，了解人药和兽药的申报流程和成药性分析。
教育背景
2017.9-2023.6 华中农业大学 预防兽医学（博士）
2011.9-2016.6 华中农业大学 动物医学（本科）
2023.6-2025.6 清华大学 生命科学院（博士后）
学术成就
以第一作者（含合著者）发表SCI论文5篇。IF大于10一篇
1. Lu H, Liu M, Lu W, Wang C, Wang G, Dong W, Wang X, Chen H, Tan C. Repurposing Ellipticine Hydrochloride to Combat Colistin-Resistant Extraintestinal Pathogenic E. coli (ExPEC). Front Microbiol. 2020 May 25;11:806. doi: 10.3389/fmicb.2020.00806. PMID: 32528422; PMCID: PMC7262907.（中科院2022.12月分区 大类二区）IF=6.064
2. Lu H, Wang C, Lu W, Li X, Wang G, Dong W, Wang X, Chen H, Tan C. Antibacterial efficacy and mechanism of Cyprinus carpio chemokine-derived L-10 against multidrug-resistant Escherichia coli infections. Int J Antimicrob Agents. 2024 Apr;63(4):107104. doi: 10.1016/j.ijantimicag.2024.107104. Epub 2024 Feb 6. PMID: 38325720.IF=10.8
3. Lu H, Wang C, Lu W, Li X, Wu Z, Wang G, Dong W, Tan C, Liu M. Apigenin and Ampicillin as Combined Strategy to Treat Severe Streptococcus suis Infection. Molecules. 2021 Apr 1;26(7):1980. doi: 10.3390/molecules26071980. PMID: 33915741; PMCID: PMC8037323.（中科院2022.12月分区 大类二区）IF=4.927
4. Lu H, Li X, Wang G, Wang C, Feng J, Lu W, Wang X, Chen H, Liu M, Tan C. Baicalein Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo. Int J Mol Sci. 2021 May 29;22(11):5829. doi: 10.3390/ijms22115829. PMID: 34072443; PMCID: PMC8199331.（中科院2022.12月分区 大类二区）IF=6.208
5. Wang C, Lu H, Li X, Zhu Y, Ji Y, Lu W, Wang G, Dong W, Liu M, Wang X, Chen H, Tan C. Identification of an anti-virulence drug that reverses antibiotic resistance in multidrug resistant bacteria. Biomed Pharmacother. 2022 Sep;153:113334. doi: 10.1016/j.biopha.2022.113334. Epub 2022 Jul 4. PMID: 35797943.(co-author)（中科院2022.12月分区 大类二区，小类一区）IF=7.419
6. Lu H, Lu W, Zhu Y, Wang C, Shi L, Li X, Wu Z, Wang G, Dong W, Tan C, Liu M. Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe Streptococcus suis Infections. Antibiotics (Basel). 2020 Dec 30;10(1):26. doi: 10.3390/antibiotics10010026. PMID: 33396878; PMCID: PMC7823847.(co-author)（中科院2022.12月分区 大类三区）IF=5.222
7. Xiao X, Lu H, Zhu W, Zhang Y, Huo X, Yang C, Xiao S, Zhang Y, Su J. A Novel Antimicrobial Peptide Derived from Bony Fish IFN1 Exerts Potent Antimicrobial and Anti-Inflammatory Activity in Mammals. Microbiol Spectr. 2022 Apr 27;10(2):e0201321. doi: 10.1128/spectrum.02013-21. Epub 2022 Mar 15. PMID: 35289673; PMCID: PMC9045357.（中科院2022.12月分区 大类一区，小类一区）IF=9.043
8. Wang C, Lu H, Liu M, Wang G, Li X, Lu W, Dong W, Wang X, Chen H, Tan C. Effective Antibacterial and Antihemolysin Activities of Ellipticine Hydrochloride against Streptococcus suis in a Mouse Model. Appl Environ Microbiol. 2021 Apr 27;87(10):e03165-20. doi: 10.1128/AEM.03165-20. PMID: 33674433; PMCID: PMC8117749.
9. Dong W, Wang G, Feng J, Li P, Wang R, Lu H, Lu W, Wang C, Wang X, Chen H, Xiang Y, Tan C. MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1. iScience. 2022 Apr 22;25(5):104279. doi: 10.1016/j.isci.2022.104279. PMID: 35586071; PMCID: PMC9108763.
10. Lu W, Tan J, Lu H, Wang G, Dong W, Wang C, Li X, Tan C. Function of Rhs proteins in porcine extraintestinal pathogenic Escherichia coli PCN033. J Microbiol. 2021 Sep;59(9):854-860. doi: 10.1007/s12275-021-1189-2. Epub 2021 Aug 12. PMID: 34382147.
11. Chen T, Wang C, Hu L, Lu H, Song F, Zhang A, Wang X, Chen H, Tan C. Evaluation of the immunoprotective effects of IF-2 GTPase and SSU05-1022 as a candidate for a Streptococcus suis subunit vaccine. Future Microbiol. 2021 Jul;16:721-729. doi: 10.2217/fmb-2020-0232. Epub 2021 Jul 5. PMID: 34223787.
12. Wang G, Tang J, Feng J, Dong W, Huo X, Lu H, Wang C, Lu W, Wang X, Chen H, Tan C. Activity of Oritavancin and Its Synergy with Other Antibiotics against Mycobacterium abscessus Infection In Vitro and In Vivo. Int J Mol Sci. 2021 Jun 14;22(12):6346. doi: 10.3390/ijms22126346. PMID: 34198513; PMCID: PMC8231898.
13. Dong W, Wang R, Li P, Wang G, Ren X, Feng J, Lu H, Lu W, Wang X, Chen H, Tan C. Orphan response regulator Rv3143 increases antibiotic sensitivity by regulating cell wall permeability in Mycobacterium smegmatis. Arch Biochem Biophys. 2020 Oct 15;692:108522. doi: 10.1016/j.abb.2020.108522. Epub 2020 Aug 8. PMID: 32781051.
14. Hu L, Wang C, Lu W, Lu H, Chen H, Tan C. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress. Microb Pathog. 2020 Oct;147:104357. doi: 10.1016/j.micpath.2020.104357. Epub 2020 Jun 27. PMID: 32603765.
15. Wang G, Dong W, Lu H, Lu W, Feng J, Wang X, Chen H, Liu M, Tan C. Enniatin A1, A Natural Compound with Bactericidal Activity against Mycobacterium tuberculosis In Vitro. Molecules. 2019 Dec 20;25(1):38. doi: 10.3390/molecules25010038. PMID: 31861925; PMCID: PMC6982829.
国家发明专利
1. （已批准）一种抗菌肽及其应用 CN202110708691.0 谭臣，鲁浩，鲁文嘉，王晨晨，李晓丹，王高岩
2. 羟氯扎胺在制备抗猪链球菌的药物中的应用 CN201811400606 谭臣 鲁浩 鲁文嘉 陈焕春 王湘如 王晨晨 朱永为 王高岩
3. （已批准）一种抗菌化合物及其应用 CN. 202110707221.2 谭臣，鲁浩，朱永为，王晨晨，鲁文嘉，王高岩
4. 羟氯扎氨在抗猪链球菌溶血素中的应用 CN.202110708619.8 谭臣，鲁浩，王晨晨，鲁文嘉，王高岩，李晓丹
5. （已批准）玫瑰树碱盐酸盐在制备抗猪链球菌溶血素的药物中的应用CN.202011122145.0 谭臣，鲁浩，刘曼莉，王晨晨，鲁文嘉，李晓丹，王湘如，陈焕春
